Phosphine
Controlled Substances
Names
[ CAS No. ]:
7803-51-2
[ Name ]:
Phosphine
[Synonym ]:
MFCD00011435
Phosphine
Amidophosphorsaeure-monoaethylester
hydrogen phosphide
O-Ethylphosphoramidat
phosphorane
EINECS 232-260-8
ethylphosphoramidate
ethyl hydrogen phosphoramidate
Phosphoramidic acid,monoethyl ester
Chemical & Physical Properties
[ Density]:
1.15 (vs air)
[ Boiling Point ]:
-87.2±9.0 °C at 760 mmHg
[ Melting Point ]:
-133.78ºC
[ Molecular Formula ]:
H3P
[ Molecular Weight ]:
33.998
[ Exact Mass ]:
33.997234
[ PSA ]:
13.59000
[ LogP ]:
0.05810
[ Vapour density ]:
1.15 (vs air)
[ Vapour Pressure ]:
27274.0±0.1 mmHg at 25°C
[ Stability ]:
Stable, but pyrophoric - spontaneously flammable in air. Note the very wide explosion limits. Incompatible with oxidizing agents, halogens, nitric acid.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SY7525000
- CHEMICAL NAME :
- Phosphine
- CAS REGISTRY NUMBER :
- 7803-51-2
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 49
- MOLECULAR FORMULA :
- H3-P
- MOLECULAR WEIGHT :
- 34.00
- WISWESSER LINE NOTATION :
- H3 P
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1000 ppm/5M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 11 ppm/4H
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 380 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 70 mg/m3/2H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2500 ppm/20M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 140 mg/m3/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 1000 ppm/5M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 ug/m3/24H/6W-C
- TOXIC EFFECTS :
- Brain and Coverings - recordings from specific areas of CNS Blood - pigmented or nucleated red blood cells Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3100 ppb/6H/13W-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 ppm/4H/4D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5 ppm/4H/2W-I
- TOXIC EFFECTS :
- Cardiac - changes in heart weight Lungs, Thorax, or Respiration - changes in lung weight Liver - changes in liver weight
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 ppm/4H/4D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 ppm/4H/2W-I
- TOXIC EFFECTS :
- Cardiac - changes in heart weight Lungs, Thorax, or Respiration - changes in lung weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,81,1994 *** REVIEWS *** ACGIH TLV-STEL 1.4 mg/m3 (1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.42 mg/m3 (0.3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD778-725 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.3 ppm (0.4 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,209,1971 OSHA PEL (Gen Indu):8H TWA 0.3 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.3 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.3 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.3 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 0.3 ppm (0.4 mg/m3);STEL 1 ppm (1 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.3 ppm (0.42 mg/m3);STEL 1 ppm (1.4 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.15 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.1 ppm (0.15 mg/m3);STEL 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-FRANCE:TWA 0.1 ppm (0.13 mg/m3);STEL 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.1 ppm (0.15 mg/m3) JAN 1993 OEL-HUNGARY:TWA 0.1 mg/m3;STEL 0.2 mg/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.3 ppm (0.4 mg/m3);STEL 1 ppm JAN 1993 OEL-THE PHILIPPINES:TWA 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-POLAND:TWA 0.1 mg/m3 JAN 1993 OEL-RUSSIA:STEL 0.1 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.15 mg/m3);STEL 0.2 ppm JAN 1993 OEL-THAILAND:TWA 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-TURKEY:TWA 0.3 ppm (0.4 mg/m3) JAN 1993 OEL-UNITED KINGDOM:STEL 0.3 ppm (0.4 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHOSPHINE-air:10H TWA 0.3 ppm;STEL 1.0 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
Safety Information
[ Symbol ]:
GHS02, GHS05, GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H220-H280-H314-H330-H400
[ Precautionary Statements ]:
P210-P260-P273-P280-P284-P305 + P351 + P338
[ Personal Protective Equipment ]:
Faceshields;Gloves;Goggles;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
[ Hazard Codes ]:
F+:Highlyflammable;T+:Verytoxic;N:Dangerousfortheenvironment;
[ Risk Phrases ]:
R12;R17;R26;R34;R50
[ Safety Phrases ]:
S28-S36/37-S45-S61-S63
[ RIDADR ]:
UN 2199
[ WGK Germany ]:
2
[ RTECS ]:
SY7525000
[ Hazard Class ]:
2.3