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Disodium dihydrogen diphosphate

Names

[ CAS No. ]:
7758-16-9

[ Name ]:
Disodium dihydrogen diphosphate

[Synonym ]:
DISODIUM PYROPHOSPHATE
Disodium dihydrogen diphosphate
SAPP 28
SAPP
disodiumdiphosphate
DSPP
MFCD00014246
EINECS 231-835-0
SAPP 40
DisodiuM pytophospha
dinatriumpyrophosphat
Phosphonate, P,P'-oxybis-, sodium salt (1:2)
sodiumpyrophosphate,acid

Biological Activity

[Description]:

Disodium pyrophosphate (SAPP), a food additive, is an inorganic compound. Disodium pyrophosphate has potential hematotoxic and immunotoxic effects[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vivo]

Disodium pyrophosphate (oral administration, 12.6 mg/kg) displays hematotoxic and immunotoxic effects with long-term exposure in rats[1]. Animal Model: Adult Sprague-Dawley rats[1] Dosage: 12.6 mg/kg Administration: Oral administration Result: Displayed significant leukopenic condition. Decreased in CD3 T-lymphocyte and CD20 Blymphocyte immunolabeling in rats. Downregulated of PPAR-α and PPAR-γ together with upregulation of TNF-α.

[References]

[1]. Yasmina M Abd-Elhakim, et al. Effects of the food additives sodium acid pyrophosphate, sodium acetate, and citric acid on hemato-immunological pathological biomarkers in rats: Relation to PPAR-α, PPAR-γ and tnfα signaling pathway. Environ Toxicol Pharmacol. 2018 Sep;62:98-106.

Chemical & Physical Properties

[ Density]:
2.311 g/cm3 (25ºC)

[ Melting Point ]:
988ºC

[ Molecular Formula ]:
H2Na2O7P2

[ Molecular Weight ]:
221.93900

[ Exact Mass ]:
221.90700

[ PSA ]:
149.57000

[ LogP ]:
0.06480

[ Stability ]:
Stable.

[ Water Solubility ]:
H2O: 0.1 M at 20 °C, clear, colorless

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UX6475000
CHEMICAL NAME :
Pyrophosphoric acid, disodium salt
CAS REGISTRY NUMBER :
7758-16-9
LAST UPDATED :
199707
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
H2-O7-P2.2Na
MOLECULAR WEIGHT :
221.94
WISWESSER LINE NOTATION :
NA2 P2-O3-Q2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2650 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,445,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,24,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
480 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,445,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
59 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,445,1957
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,47,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2309 No. of Facilities: 519 (estimated) No. of Industries: 15 No. of Occupations: 15 No. of Employees: 2961 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2309 No. of Facilities: 2180 (estimated) No. of Industries: 41 No. of Occupations: 39 No. of Employees: 48188 (estimated) No. of Female Employees: 9570 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
UX6475000

[ HS Code ]:
2835399000

Customs

[ HS Code ]: 2835399000

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