POTASSIUM NITRITE
Names
[ CAS No. ]:
7758-09-0
[ Name ]:
POTASSIUM NITRITE
[Synonym ]:
MFCD00011408
EINECS 231-832-4
potassium,nitrite
Chemical & Physical Properties
[ Density]:
1,92 g/cm3
[ Melting Point ]:
350 °C (dec.)(lit.)
[ Molecular Formula ]:
KNO2
[ Molecular Weight ]:
85.10380
[ Exact Mass ]:
84.95660
[ PSA ]:
52.49000
[ LogP ]:
0.25060
[ Stability ]:
Stability Stable, but strong oxidizer - contact with combustible material may lead to fire. Incompatible with strong reducing agents, strong acids, combustible materials, cyanides, ammonium salts.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TT3750000
- CAS REGISTRY NUMBER :
- 7758-09-0
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- N-O2.K
- MOLECULAR WEIGHT :
- 85.11
- WISWESSER LINE NOTATION :
- .KA..N-O2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 1428 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Ear) - tinnitus Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 85 gm/m3/2H
- TOXIC EFFECTS :
- Behavioral - sleep Behavioral - excitement Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18 gm/kg/13W-C
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Blood - methemoglobinemia-carboxyhemoglobin Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 30 gm/kg
- SEX/DURATION :
- male 60 day(s) pre-mating female 60 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 137 gm/kg
- SEX/DURATION :
- female 18 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 201 gm/kg
- SEX/DURATION :
- female 19 week(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - other effects to embryo
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Microorganism - not otherwise specified
- DOSE/DURATION :
- 20 mmol/L
- REFERENCE :
- JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 5,442,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83413 No. of Facilities: 205 (estimated) No. of Industries: 11 No. of Occupations: 7 No. of Employees: 1353 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83413 No. of Facilities: 788 (estimated) No. of Industries: 22 No. of Occupations: 34 No. of Employees: 27303 (estimated) No. of Female Employees: 2845 (estimated)
Safety Information
[ Symbol ]:
GHS03, GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H272-H301-H400
[ Precautionary Statements ]:
P220-P273-P301 + P310
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P2 (EN 143) respirator cartridges;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
O: Oxidizing agent;T: Toxic;N: Dangerous for the environment;
[ Risk Phrases ]:
R8;R25;R50
[ Safety Phrases ]:
S45-S61
[ RIDADR ]:
UN 1488 5.1/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
TT3750000
[ Packaging Group ]:
II
[ Hazard Class ]:
5.1
[ HS Code ]:
2834100000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2834100000
Articles
Biochem. Pharmacol. 90(2) , 188-95, (2014)
The aim of the present study was to identify cytochrome P450 isoenzymes (CYPs) involved in the 5-sulfoxidation and N-demethylation of the aliphatic-type phenothiazine neuroleptic levomepromazine in hu...
Nitrate (NO3(-)) and nitrite (NO2(-)) are endocrine disruptors to downregulate expression of tyrosine hydroxylase and motor behavior through conversion to nitric oxide in early development of zebrafish.Biochem. Biophys. Res. Commun. 452(3) , 608-13, (2014)
With a view to consider the increasing concern over nitrogen pollution in the aquatic environment, we investigated effects of nitrate (NO3(-)) and nitrite (NO2(-)) on the activity of dopaminergic neur...
Plant-fungal ecology. Niche engineering demonstrates a latent capacity for fungal-algal mutualism.Science 345(6192) , 94-8, (2014)
Mutualistic symbioses shape the evolution of species and ecosystems and catalyze the emergence of biological complexity, yet how such symbioses first form is unclear. We show that an obligate mutualis...