Dox-Ph-PEG1-Cl

Names

[ Name ]:
Dox-Ph-PEG1-Cl

Biological Activity

[Description]:

PROTAC Linker 34 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 34 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₃ClO₃

[ Molecular Weight ]:
228.67

[ Storage condition ]:
2-8°C