SL 0101-1

Names

[ Name ]:
SL 0101-1

[Synonym ]:
4H-1-Benzopyran-4-one, 3-[(3,4-di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
3',4'-Di-O-acetylafzelin
5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl 3,4-di-O-acetyl-6-deoxy-α-L-mannopyranoside
3",4"-Diacetylafezelin
SL 0101-1
SL0101

Biological Activity

[Description]:

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. Shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> Ribosomal S6 Kinase (RSK)

[Target]

IC50: 89 nM (RSK)[1].

[References]

[1]. Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
753.0±60.0 °C at 760 mmHg

[ Melting Point ]:
128-132ºC

[ Molecular Formula ]:
C₂₅H₂₄O₁₂

[ Molecular Weight ]:
516.451

[ Flash Point ]:
255.6±26.4 °C

[ Exact Mass ]:
516.126770

[ PSA ]:
182.19000

[ LogP ]:
2.75

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.666

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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