4-Phenylpiperidine

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
259.9±29.0 °C at 760 mmHg

[ Melting Point ]:
61-65 °C(lit.)

[ Molecular Formula ]:
C₁₁H₁₅N

[ Molecular Weight ]:
161.243

[ Flash Point ]:
113.0±19.7 °C

[ Exact Mass ]:
161.120453

[ PSA ]:
12.03000

[ LogP ]:
2.39

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.522

Click to get detail MSDS

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S45-S37/39-S36/37

[ RIDADR ]:
UN 2922 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
TM2625000

[ HS Code ]:
2933399090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

A strategy for isotope containment during radiosynthesis--devolatilisation of bromobenzene by fluorous-tagging-Ir-catalysed borylation en route to the 4-phenylpiperidine pharmacophore.

Org. Biomol. Chem. 6 , 4093-4095, (2008)

Syntheses of two 4-phenylpiperidines from bromobenzene have been developed involving anchoring to a fluorous-tag, Ir-catalysed borylation, Pd- and Co-catalysed elaboration then traceless cleavage. Alt...

Structure-activity studies of morphine fragments. I. 4-alkyl-4-(m-hydroxy-phenyl)-piperidines.

Mol. Pharmacol. 34(3) , 363-76, (1988)

The 4-(m-OH-phenyl)piperidines are a flexible fragment of the morphine/benzomorphan fused-ring opioids. Analogs in this family were synthesized with varying 4-alkyl substituents increasing in bulk fro...

Radical-mediated nitrile translocation as the key step in the stereoselective transformation of 2-(4-chloro-2-cyanobutyl)aziridines to methyl cis-(1-arylmethyl-4-phenylpiperidin-2-yl)acetates.

Org. Biomol. Chem. 10(16) , 3308-14, (2012)

Non-activated 2-(4-chloro-2-cyano-2-phenylbutyl)aziridines were used as building blocks for the stereoselective synthesis of novel cis-2-cyanomethyl-4-phenylpiperidines via a microwave-assisted azirid...

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