ethoheptazine
Names
[ CAS No. ]:
77-15-6
[ Name ]:
ethoheptazine
[Synonym ]:
1-Methyl-4-phenyl-hexahydro-azepin-4-carbonsaeure-aethylester
ETHOHEPTAZINE
Etoheptazina [INN-Spanish]
Zactane
Ethoheptazinum [INN-Latin]
(+-)-1-methyl-4-phenyl-hexahydro-azepine-4-carboxylic acid ethyl ester
Aethoheptazin
Ethoheptazine [BAN]
Ethyl heptazine
Chemical & Physical Properties
[ Density]:
1.037 g/cm3
[ Boiling Point ]:
346.4ºC at 760 mmHg
[ Molecular Formula ]:
C16H23NO2
[ Molecular Weight ]:
261.35900
[ Flash Point ]:
114.4ºC
[ Exact Mass ]:
261.17300
[ PSA ]:
29.54000
[ LogP ]:
2.54110
[ Index of Refraction ]:
1.514
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CM2800000
- CHEMICAL NAME :
- Azepine-4-carboxylic acid, hexahydro-1-methyl-4-phenyl-, ethyl ester
- CAS REGISTRY NUMBER :
- 77-15-6
- BEILSTEIN REFERENCE NO. :
- 0088192
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C16-H23-N-O2
- MOLECULAR WEIGHT :
- 261.40
- WISWESSER LINE NOTATION :
- T7NTJ A1 DVO2 DR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 355 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,51,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 34 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,51,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Implant
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 277 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,51,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 318 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,51,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 134,154,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Implant
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 167 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,51,1969