CAY10434

Names

[ Name ]:
CAY10434

[Synonym ]:
1-Hexanamine, 6-[4-(1H-imidazol-1-yl)phenoxy]-N,N-dimethyl-
6-[4-(1H-Imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine
6-[4-(1H-imidazol-1-yl)phenoxy]-N,N-dimethylhexan-1-amine

Biological Activity

[Description]:

CAY 10434 is a potent CYP4A hydroxylase inhibitor. CAY 10434 improves contractile response to angiotensin II with the maximal contractile response (Emax) 6764 mg[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

[In Vitro]

CAY 10434 (1 µM；30 分钟) 结合咪康唑可增加内皮完整主动脉环中血管紧张素 II 的累积[1]。

[References]

[1]. Jerez S, et al. 17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins. Prostaglandins Other Lipid Mediat. 2012 Jan;97(1-2):36-42.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
435.0±30.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₆N₃O+

[ Molecular Weight ]:
287.400

[ Flash Point ]:
216.9±24.6 °C

[ Exact Mass ]:
287.199768

[ PSA ]:
27.84000

[ LogP ]:
3.33

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.539

[ Storage condition ]:
-20°C

Related Compounds

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