8-Bromo-cAMP sodium salt

Names

[ Name ]:
8-Bromo-cAMP sodium salt

[Synonym ]:
4H-Furo[3,2-d]-1,3,2-dioxaphosphorin-7-ol, 6-(6-amino-8-bromo-9H-purin-9-yl)tetrahydro-2-hydroxy-, 2-oxide, sodium salt, (4aR,6R,7R,7aS)- (1:1)
8-BROMOADENOSINE 3':5'-CYCLICMONOPHOSPHA TE SODIUM
CAMP,8-BR,NA
8-BROMOADENOSINE-3',5'-CYCLOPHOSPHATE SODIUM SALT
8-BR-CAMP NA
Sodium (4aR,6R,7R,7aS)-6-(6-amino-8-bromo-9H-purin-9-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide
8-BROMO-CAMP,NA
8-bromoadenosine 3:5-cyclic*monophosphate sodiu
8-BROMO-CAMP,SODIUM SALT
8-BR-CAMP SODIUM SALT
8-Bromoadenosine 3',5'-phosphoric acid sodium salt
MFCD00005844
8-BROM-ADENOSIN-3',5'-CYCLOPHOSPHAT

Biological Activity

[Description]:

8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt), a cyclic AMP analog, is an activator of cyclic AMP-dependent protein kinase (PKA)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA

Signaling Pathways >> Stem Cell/Wnt >> PKA

[Target]

PKA[1]

[In Vitro]

8-Bromo-cAMP sodium salt is a brominated derivative of cyclic AMP. 8-Bromo-cAMP sodium salt enhances the efficiency of cellular reprogramming. 8-Bromo-cAMP sodium salt improves the reprogramming efficiency of human neonatal foreskin fibroblast (HFF1) cells. 8-Bromo-cAMP sodium salt inhibits proliferation, induce differentiation and apoptosis in a malignant glioma cell line (A-172) and an esophageal cancer cell line (Eca-109)[1].

[References]

[1]. Wang Y, et al. A cyclic AMP analog, 8-Br-cAMP, enhances the induction of pluripotency in human fibroblast cells. Stem Cell Rev. 2011 Jun;7(2):331-41.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₀BrN₅NaO₆P

[ Molecular Weight ]:
430.08

[ Exact Mass ]:
428.944977

[ PSA ]:
167.48000

[ LogP ]:
0.96450

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 100 mg/mL

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

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Cell Death Differ. 22 , 1970-84, (2015)

Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinuclea...

Immunomodulatory effects of Lippia sidoides extract: induction of IL-10 through cAMP and p38 MAPK-dependent mechanisms.

J. Med. Food 18(3) , 370-7, (2015)

Lippia sidoides is an aromatic shrub that grows wild in the northeastern region of Brazil. In local traditional medicine, the aerial portions of this species are used as anti-infectives, antiseptics, ...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Related Compounds

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