Squalene

Names

[ Name ]:
Squalene

[Synonym ]:
Sqalene
2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-
2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene
Squalene
spinacene
supraene
2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene
SQUALENE OIL
Skvalen

Biological Activity

[Description]:

(E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

(E/Z)-Squalene (0-50 μM) 在人乳腺上皮细胞 (MCF10A) 中，降低细胞内 ROS 水平，防止 H2O2 诱导的氧化损伤，并保护细胞免受 DNA 氧化损伤[1]。

[References]

[1]. Lou-Bonafonte JM, et al. Current Insights into the Biological Action of Squalene. Mol Nutr Food Res. 2018 Jun 8:e1800136.

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
429.3±0.0 °C at 760 mmHg

[ Melting Point ]:
-75ºC(lit.)

[ Molecular Formula ]:
C₃₀H₅₀

[ Molecular Weight ]:
410.718

[ Flash Point ]:
254.1±22.2 °C

[ Exact Mass ]:
410.391266

[ LogP ]:
13.09

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.492

[ Storage condition ]:
2-8°C

Safety Information

[ Safety Phrases ]:
24/25

[ WGK Germany ]:
2

[ RTECS ]:
XB6010000

[ HS Code ]:
2901299090

Customs

[ HS Code ]: 2901299090

[ Summary ]:
2901299090 unsaturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%