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N'-Nitro-L-arginine benzyl ester

Names

[ CAS No. ]:
7672-27-7

[ Name ]:
N'-Nitro-L-arginine benzyl ester

[Synonym ]:
Nω-nitro-L-arginine benzyl ester
Ng-nitro-L-arginine benzyl ester
Nε-Nitro-L-arginin-benzylester
N'-Nitro-L-arginine benzyl ester

Biological Activity

[Description]:

L-NABE is a nitric oxide (NO) synthase inhibitor. L-NABE is also a potent endothelium dependent vasoconstrictor and inhibitor of relaxation[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Immunology/Inflammation >> NO Synthase

[References]

[1]. Nossaman BD, et al. Nomega-Nitro-L-Arginine Benzyl Ester Enhances Pulmonary Vasopressor Responses to Hypoxia and to Angiotensin II. Am J Ther. 1995 Jul;2(7):462-468.  

[2]. G Thomas, et al. NW-nitro L-arginine benzyl ester, a potent irreversible inhibitor of endothelium dependent relaxation. Biochem Biophys Res Commun. 1991 Sep 30;179(3):1677-82.  

Chemical & Physical Properties

[ Density]:
1.37

[ Boiling Point ]:
456.8±55.0 °C(Predicted)

[ Melting Point ]:
132-134 ºC

[ Molecular Formula ]:
C13H19N5O4

[ Molecular Weight ]:
309.32

[ Exact Mass ]:
309.14400

[ PSA ]:
146.05000

[ LogP ]:
2.24800

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds