4-Bromo-antibiotic

Names

[ Name ]:
4-Bromo-antibiotic

Biological Activity

[Description]:

4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187，a calcium modulator, induces apoptosis in different cells, including HL-60 cells[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Zhu WH, et al. Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells. Life Sci. 1995;57(23):2091-9.

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
735.4ºC at 760 mmHg

[ Molecular Formula ]:
C₂₉H₃₆BrN₃O₆

[ Molecular Weight ]:
602.51700

[ Flash Point ]:
398.5ºC

[ Exact Mass ]:
601.17900

[ PSA ]:
126.68000

[ LogP ]:
6.36530

[ Index of Refraction ]:
1.628

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Articles

Mast cell histamine-induced calcium transients in cultured human peritoneal mesothelial cells.

Perit. Dial. Int. 18(6) , 626-36, (1998)

Peritoneal inflammation results from a complex interplay of events initiated by macrophage activity in response to infection, with the stimulation of mesothelial cell cytokine release amplifying the r...

Activity-dependent development of calcium regulation in growing motor axons.

J. Neurosci. 18(13) , 4966-72, (1998)

In cultured nerve cord explants from the crayfish (Procambarus clarkii), the normal impulse activity levels of growing motor axons determine their response to Ca2+ influx. During depolarization or Ca2...

Intestinal anion exchanger down-regulated in adenoma (DRA) is inhibited by intracellular calcium.

J. Biol. Chem. 284(29) , 19744-53, (2009)

The Na/H exchanger 3 (NHE3) and the Cl/HCO(3) exchanger down-regulated in adenoma (DRA) together facilitate intestinal electroneutral NaCl absorption. Elevated Ca(2+)(i) inhibits NHE3 through mechanis...

Related Compounds

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