Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran] alpha-D-glucopyranoside deriv.

Names

[ Name ]:
Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran] alpha-D-glucopyranoside deriv.

[Synonym ]:
PolyphyllinC
(3β,25R)-Spirost-5-en-3-yl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl 3-O-(6-deoxy-α-L-mannopyranosyl)-

Biological Activity

[Description]:

Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC50=36.87 µM) activities against the tyrosinase and moderate (IC50=1.59 µg/mL) antileishmanial activities[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[Target]

IC50: 36.87 µM (tyrosinase)[1]

[References]

[1]. Devkota KP, et, al. Tyrosinase inhibitory and antileishmanial constituents from the rhizomes of Paris polyphylla. Nat Prod Res. 2007 Apr;21(4):321-7.

[2]. Singh SB, et, al. Spirostanol saponins from Paris polyphylla, structures of polyphyllin C, D, E and F. Phytochemistry.1980; 21(12): 2925-2929.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
849.1±65.0 °C at 760 mmHg

[ Melting Point ]:
189-192 °C

[ Molecular Formula ]:
C₃₉H₆₂O₁₂

[ Molecular Weight ]:
722.902

[ Flash Point ]:
467.3±34.3 °C

[ Exact Mass ]:
722.424133

[ PSA ]:
176.76000

[ LogP ]:
6.70

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.605

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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