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Piptocarphin F

Names

[ CAS No. ]:
76215-53-7

[ Name ]:
Piptocarphin F

Biological Activity

[Description]:

Piptocarphin F (Compound 5) is a sesquiterpene lactone. Piptocarphin F shows cytotoxic activity on human leukemia cell lineHL-60 (IC50=5.69 μmol*L-1)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. LIAO, S.-G., et al. Cytotoxic sesquiterpene lactones from Vernonia bockiana. Chinese Journal of Natural Medicines. 2012 May 20;10(3):230–233.

Chemical & Physical Properties

[ Density]:
1.3g/cm3

[ Boiling Point ]:
573.4ºC at 760 mmHg

[ Molecular Formula ]:
C21H28O8

[ Molecular Weight ]:
408.44

[ Flash Point ]:
197ºC

[ Exact Mass ]:
408.17800

[ PSA ]:
111.52000

[ LogP ]:
1.66050

[ Index of Refraction ]:
1.565

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UD3467000
CHEMICAL NAME :
2-Propenoic acid, 2-methyl-, 2,4,5,6,7,8,9,10-octahydro-6,7-dihydroxy-6,10-dimethy l-3- (ethoxymethyl)-2-oxo-7,10-epoxycyclodeca(b)furan-4-yl ester, (4S-(4R*,6S*,7S*,10R*,11E))-
CAS REGISTRY NUMBER :
76215-53-7
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H28-O8
MOLECULAR WEIGHT :
408.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5105 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 12,443,1985

Related Compounds

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