LONAZOLAC CALCIUM SALT

Names

[ Name ]:
LONAZOLAC CALCIUM SALT

[Synonym ]:
LONAZOLAC CALCIUM SALT
Arthro akut
Bis[1-phenyl-3-(4-chlorophenyl)-1H-pyrazole-4-acetic acid]calcium salt
Argun l
Irritren
calcium bis[3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-acetate]
Lonazolac calcium
1H-Pyrazole-4-acetic acid,3-(4-chlorophenyl)-1-phenyl-,calcium salt (2:1)
Bis[3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid]calcium salt

Biological Activity

[Description]:

Lonazolac (hemicalcium) is the calcium salt form of Lonazolac. Lonazolac is a nonsteroidal antirheumatic agent with anti-inflammatory properties[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Trnavský K, et al. [Lonazolac - a new non-steroidal antirheumatic agent. Report of a double-blind crossover clinical study]. Fysiatr Revmatol Vestn. 1983;61(3):147-152.

Chemical & Physical Properties

[ Boiling Point ]:
525.1ºC at 760 mmHg

[ Molecular Formula ]:
C₃₄H₂₄CaCl₂N₄O₄

[ Molecular Weight ]:
663.56300

[ Flash Point ]:
271.4ºC

[ Exact Mass ]:
662.08000

[ PSA ]:
115.90000

[ LogP ]:
4.97020

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ4915000

CAS REGISTRY NUMBER :: 75821-71-5

LAST UPDATED :: 199409

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C34-H24-Cl2-N4-O4.Ca

MOLECULAR WEIGHT :: 663.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 845 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,655,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 670 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 31,655,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,180,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,180,1982

Related Compounds

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