Dynorphin A (1-8)

Names

[ Name ]:
Dynorphin A (1-8)

[Synonym ]:
dynorphin A fragment 1-8
DYNORPHIN A (1-8),PORCINE
DYNORPHIN A PORCINE FRAGMENT 1-8
Ph-8p
GFL PEPTIDE STANDARD
dynorphin A (1-8)
H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-OH
YGGFLRRI
TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE
dynorphin-(1-8)

Biological Activity

[Description]:

Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM)[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[References]

[1]. Agbas A, Ahmed MS, Millington W, et al. Dynorphin A(1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Peptides. 1995;16(4):623-627.

[2]. Ahmed MS, Zhou DH, Cavinato AG, Maulik D. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 1989;44(13):861-871.

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Molecular Formula ]:
C₄₆H₇₂N₁₄O₁₀

[ Molecular Weight ]:
981.15200

[ Exact Mass ]:
980.55600

[ PSA ]:
411.05000

[ LogP ]:
3.68290

[ Index of Refraction ]:
1.637

Safety Information

[ WGK Germany ]:
3

Synthetic Route

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Related Compounds

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