Debromohymenialdisine

Names

[ Name ]:
Debromohymenialdisine

[Synonym ]:
Pyrrolo[2,3-c]azepin-8(1H)-one, 4-(2-amino-3,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydro-, (4Z)-
2c3j
(Z)-2-Debromohymenialdisine
(4Z)-4-(2-Amino-5-oxo-1,5-dihydro-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one
Debromohymenialdisine
(Z)-Debromohymenialdisine
debromohymenialdesine

Biological Activity

[Description]:

Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC50 value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> MEK

Signaling Pathways >> MAPK/ERK Pathway >> Raf

[Target]

IC50: 881 nM (in Raf/MEK-1/MAPK signaling cascade assay)[1].

[In Vitro]

Debromohymenialdisine has moderate inhibitory activity with an IC50 value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay[1].

[References]

[1]. Deniz Tasdemir, et al. Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem. 2002 Jan 17;45(2):529-32.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Melting Point ]:
>250ºC (dec.)

[ Molecular Formula ]:
C₁₁H₁₁N₅O₂

[ Molecular Weight ]:
245.237

[ Exact Mass ]:
245.091278

[ PSA ]:
116.85000

[ LogP ]:
-0.14

[ Index of Refraction ]:
1.878

Related Compounds

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