Org 48762-0

Names

[ CAS No. ]:
755753-89-0

[ Name ]:
Org 48762-0

[Synonym ]:
2H-Pyrazolo[3,4-b]pyridine, 4,6-bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)-
4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)-2H-pyrazolo[3,4-b]pyridine
MFCD30536377

Biological Activity

[Description]:

Org 48762-0 is a potent, orally active and selective p38 inhibitor with EC50 of 0.1 μM. Org 48762-0 reduces LPS-induced TNFα release and prevents bone damage in collagen-induced arthritis in mice[1].

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK
Research Areas >> Inflammation/Immunology

[References]

[1]. K Mihara, et al. A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha. Br J Pharmacol. 2008 May;154(1):153-64.   

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
520.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H16F2N4

[ Molecular Weight ]:
398.41

[ Flash Point ]:
268.3±30.1 °C

[ Exact Mass ]:
398.134308

[ LogP ]:
3.62

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.661

Related Compounds