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Albendazole sulfone

Names

[ CAS No. ]:
75184-71-3

[ Name ]:
Albendazole sulfone

[Synonym ]:
albendazole sulfone

Biological Activity

[Description]:

Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1][2].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Ingold K, et, al. Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. Antimicrob Agents Chemother. 1999 May;43(5):1052-61.

[2]. Adas G, et, al. Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study). World J Gastroenterol. 2009 Jan 7;15(1):112-6.

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Melting Point ]:
290-292ºC

[ Molecular Formula ]:
C12H15N3O4S

[ Molecular Weight ]:
297.33000

[ Exact Mass ]:
297.07800

[ PSA ]:
109.53000

[ LogP ]:
3.07870

[ Index of Refraction ]:
1.619

[ Storage condition ]:
-20°C Freezer

[ Water Solubility ]:
Soluble in DMSO, and methanol.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD6520700
CHEMICAL NAME :
2-Benzimidazolecarbamic acid, 5-(propylsulfonyl)-, methyl ester
CAS REGISTRY NUMBER :
75184-71-3
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H15-N3-O4-S
MOLECULAR WEIGHT :
297.36
WISWESSER LINE NOTATION :
T56 BM DNJ CMVO1 GSW3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
75 mg/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 12,159,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
75 mg/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 12,159,1981

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H361d

[ Precautionary Statements ]:
P281-P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
63-36/38

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
DD6520700

[ HS Code ]:
29339900

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