YC-001

Names

[ Name ]:
YC-001

[Synonym ]:
4-(5-Chloro-2-thienyl)-3-(2-thienyl)-2(5H)-furanone
2(5H)-Furanone, 4-(5-chloro-2-thienyl)-3-(2-thienyl)-
MFCD03948015

Biological Activity

[Description]:

YC-001 is a novel pharmacological chaperone of rod photoreceptor opsin, rescues the transport of multiple rod opsin mutants in mammalian cells; demonstrates micromolar potency and efficacy greater than 9-cis-retinal with lower cytotoxicity; binds to bovine rod opsin with an EC50 (8.7 uM) similar to 9-cis-retinal, improves the glycosylation of the P23H-opsin mutant; YC-001 is an inverse agonist and antagonist of rod opsin that non-competitively antagonizes rod opsin signaling, delays isorhodopsin pigment regeneration; protects Abca4 -/- Rdh8 -/- mice from bright light-induced retinal degeneration.

[References]

References 1. Chen Y, et al. Nat Commun. 2018 May 17;9(1):1976. View Related Products by Target Other Targets

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
494.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₇ClO₂S₂

[ Molecular Weight ]:
282.766

[ Flash Point ]:
252.7±28.7 °C

[ Exact Mass ]:
281.957611

[ LogP ]:
3.35

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.686

Related Compounds

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