<Suppliers Price>

Pyronaridine

Names

[ CAS No. ]:
74847-35-1

[ Name ]:
Pyronaridine

[Synonym ]:
4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol
C29H32ClN5O2
4-[(7-Chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol
Benzonaphthyridine 7351
Malaridine
pyronaridine phosphate salt
Phenol, 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)-
Pyronaridine
UNII-TD3P7Q3SG6
4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol

Biological Activity

[Description]:

Pyronaridine is an orally active Mannich base anti-malarial agent. Pyronaridine is active against P. falciparum and Echinococcus granulosus infection[1][2].

[Related Catalog]:

Research Areas >> Infection

[In Vitro]

Pyronaridine (24 h) shows anti-P. falciparum activity with an IC50 value of 1.53-3.94 nM[1].

[In Vivo]

Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) reduces the parasitic burden in the Echinococcus granulosus-infected mice[2]. Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) reduces the parasitic burden in secondarily infected (cysts) mice[2]. Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) exhibits a higher exposure in the liver than in the plasma in male ICR mice[2]. Animal Model: Echinococcus granulosus-infected mice model[2] Dosage: 57 mg/kg Administration: Oral administration, q.d. for 30 days Result: Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
621.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C29H32ClN5O2

[ Molecular Weight ]:
518.050

[ Flash Point ]:
329.6±31.5 °C

[ Exact Mass ]:
517.224426

[ PSA ]:
76.72000

[ LogP ]:
4.80

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.720

[ Storage condition ]:
-20℃

Related Compounds