7H-Furo[3,2-g][1]benzopyran-7-one, 4-hydroxy-9-methoxy-

Names

[ Name ]:
7H-Furo[3,2-g][1]benzopyran-7-one, 4-hydroxy-9-methoxy-

[Synonym ]:
4-Hydroxy-9-methoxy-furo[3,2-g]chromen-7-on
xanthotoxin
4-hydroxy-9-methoxy-7H-furo<3,2-g><1>benzopyran-7-one
4-hydroxy-9-methoxy-furo[3,2-g]chromen-7-one
5-hydroxy-8-methoxypsoralen
5-Hydroxyxanthotoxin
8-methoxy-5-hydroxypsoralen

Biological Activity

[Description]:

5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite of Xanthotoxin. Xanthotoxin is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Alsharari SD, et al. Pharmacokinetic and Pharmacodynamics Studies of Nicotine After Oral Administration in Mice: Effects of Methoxsalen, a CYP2A5/6 Inhibitor. Nicotine Tob Res. 2014 Jan;16(1):18-25.

Chemical & Physical Properties

[ Density]:
1.484g/cm3

[ Boiling Point ]:
342.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₈O₅

[ Molecular Weight ]:
232.18900

[ Flash Point ]:
161.1ºC

[ Exact Mass ]:
232.03700

[ PSA ]:
72.81000

[ LogP ]:
2.25340

[ Index of Refraction ]:
1.67

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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