Cloricromenehydrochloride

Names

[ Name ]:
Cloricromenehydrochloride

[Synonym ]:
AD6
Cloricromen hydrochloride
Proendotel (TN)
8-Chloro-3-(2-diethylaminoethyl)-7-ethoxycarbonylmethoxy-4-methylcoumarin hydrochloride
Cloricromen hydrohloride

Biological Activity

[Description]:

Cloricromen (Cloricromene) hydrochloride is a platelet aggregation inhibitor. Cloricromen hydrochloride can inhibit platelet aggregation in man and in experimental thrombosis[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. G Orefice, et al. No effect of cloricromen on some coagulation parameters in patients with ischaemic cerebrovascular disease. J Int Med Res. 1994 Sep-Oct;22(5):287-91.

Chemical & Physical Properties

[ Boiling Point ]:
538ºC at 760 mmHg

[ Melting Point ]:
221-222.3ºC

[ Molecular Formula ]:
C₂₀H₂₇Cl₂NO₅

[ Molecular Weight ]:
432.33800

[ Flash Point ]:
279.2ºC

[ Exact Mass ]:
431.12700

[ PSA ]:
68.98000

[ LogP ]:
4.38300

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
AF8970000

Articles

Cloricromene in endotoxemia: role of NF-kappaB.

Naunyn Schmiedebergs Arch. Pharmacol. 370(2) , 140-5, (2004)

In this study we investigated, for the first time in vivo, the effect of cloricromene, a cumarine derivative, on NF-kappaB activation in endotoxin-treated rats. Endotoxemia was induced in male rats by...

Tumor necrosis factor induces E-selectin production in splanchnic artery occlusion shock.

Am. J. Physiol. 268(4 Pt 2) , H1412-7, (1995)

Splanchnic arteries were clamped for 45 min to induce splanchnic artery occlusion (SAO) shock in anesthetized rats. Sham-operated animals were used as controls. Survival time, serum tumor necrosis fac...

Preparation and characterization of eudragit retard nanosuspensions for the ocular delivery of cloricromene.

AAPS PharmSciTech 7(1) , E27, (2006)

The purpose of this study was to improve the stability of cloricromene (AD6) in ophthalmic formulations and its drug availability at the ocular level. To this end, AD6-loaded polymeric nanoparticle su...

Related Compounds

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