BIO-013077-01

Names

[ CAS No. ]:
746667-48-1

[ Name ]:
BIO-013077-01

[Synonym ]:
6-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoxaline
Quinoxaline

Biological Activity

[Description]:

BIO-013077-01 is a pyrazole TGF-β inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies[1].

[In Vivo]

TGF-β Inhibitor

[References]

[1]. Jin CH, et al. Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors. Eur J Med Chem. 2011 Sep;46(9):3917-25.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₃N₅

[ Molecular Weight ]:
287.31900

[ Exact Mass ]:
287.11700

[ PSA ]:
67.35000

[ LogP ]:
3.39030

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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