(D-Arg8)-Inotocin

Names

[ Name ]:
(D-Arg8)-Inotocin

Biological Activity

[Description]:

(D-Arg8)-Inotocin is a potent, selective and competitive antagonist of vasopressin receptor (V1aR), with a Ki of 1.3 nM. (D-Arg8)-Inotocin shows more than 3000-fold selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor

[References]

[1]. Giglio MGD, et, al. Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Sci Rep. 2017 Feb 1;7:41002.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₉H₆₈N₁₄O₁₁S₂

[ Molecular Weight ]:
973.17

Related Compounds

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