Antileishmanial agent-23

Names

[ Name ]:
Antileishmanial agent-23

[Synonym ]:
1,3,4-Oxadiazole, 2-(1,3-benzodioxol-5-yl)-5-[[[4,5-dihydro-2-(4-methoxyphenyl)-5-thiazolyl]methyl]thio]-

Biological Activity

[Description]:

Antileishmanial agent-23 (compound G1/9) is a potent and selective trypanothione reductase (TR) inhibitor, with an IC50 of 2.24 ± 0.52 μM. Antileishmanial agent-23 inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Ilari A, et al. Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors. Mol Pharm. 2018 Aug 6;15(8):3069-3078.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₇N₃O₄S₂

[ Molecular Weight ]:
427.50

Related Compounds

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