benzyl N-[(2S)-1-[(3-bromo-4,5-dihydro-1,2-oxazol-5-yl)methylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamate

Names

[ Name ]:
benzyl N-[(2S)-1-[(3-bromo-4,5-dihydro-1,2-oxazol-5-yl)methylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamate

Biological Activity

[Description]:

KCC009, a transglutaminase 2 (TG2) inhibitor, induces p53-independent radiosensitization[1][2].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

The inhibition rates were 15.33±1.46 (%) for H1299/WT-p53 cells, and 14.31±1.90 (%) for H1299/M175H-p53 cells when cells were treated with KCC009 at concentration of 3.91 uM[1].

[References]

[1]. Sheng Huaying, et al. Transglutaminase 2 Inhibitor KCC009 Induces p53-Independent Radiosensitization in Lung Adenocarcinoma Cells. Med Sci Monit. 2016 Dec 21;22:5041-5048.

[2]. L Yuan, et al. Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₂BrN₃O₅

[ Molecular Weight ]:
476.32000

[ Exact Mass ]:
475.07400

[ PSA ]:
116.23000

[ LogP ]:
3.32350

Related Compounds

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