Dazoxiben

Names

[ CAS No. ]:
74226-22-5

[ Name ]:
Dazoxiben

[Synonym ]:
Dazoxiben hydrochloride
Dazoxiben HCl

Biological Activity

[Description]:

Dazoxiben is a potent and orally active thromboxane (TX) synthase inhibitor[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

Research Areas >> Inflammation/Immunology

[Target]

Thromboxane (TX) synthase[1]

[In Vitro]

Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production[1]. Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC50 of 1.60 μM) than in rat whole blood (IC50= 0.32μM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production[1].

[In Vivo]

Dazoxiben (intraperitoneal administration; 100 μg/kg) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs[2].

[References]

[1]. Patrignani P, et al. Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism.J Pharmacol Exp Ther. 1984 Feb;228(2):472-7.

[2]. Yu SM, et al. Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor.Br J Pharmacol. 1994 Mar;111(3):906-12.

Chemical & Physical Properties

[ Boiling Point ]:
491.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₃ClN₂O₃

[ Molecular Weight ]:
268.69600

[ Flash Point ]:
250.9ºC

[ Exact Mass ]:
268.06100

[ PSA ]:
64.35000

[ LogP ]:
2.46230

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.