7-Acetyllycopsamine

Names

[ Name ]:
7-Acetyllycopsamine

[Synonym ]:
[(1R,7aR)-1-Acetoxy-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl]methyl (2S,3S)-2,3-dihydroxy-2-isopropylbutanoate
Acetyllycopsamine
Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, ((1R,7aR)-1-(acetyloxy)-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl)methyl ester, (2S,3S)-
Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, [(1R,7aR)-1-(acetyloxy)-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-yl]methyl ester, (2S,3S)-

Biological Activity

[Description]:

7-Acetyllycopsamine, a pyrrolizidine alkaloid, is a mild hepatotoxin. 7-Acetyllycopsamine can induce liver inflammation in mice[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[In Vivo]

7-Acetyllycopsamine (750 mg/kg; single dose) induces liver inflammation, detectable as significantly greater serum ALT (alanine transaminase) scores than controls in C57BL/6J male mice[1].

[References]

[1]. Oliver Robinson, et al. Hirmi Valley liver disease: a disease associated with exposure to pyrrolizidine alkaloids and DDT. J Hepatol. 2014 Jan;60(1):96-102.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
466.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₇NO₆

[ Molecular Weight ]:
341.399

[ Flash Point ]:
235.6±28.7 °C

[ Exact Mass ]:
341.183838

[ LogP ]:
0.16

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.546

[ Storage condition ]:
-20°C

Related Compounds

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