Decanedioic acid-d16

Names

[ Name ]:
Decanedioic acid-d16

Biological Activity

[Description]:

Decanedioic acid-d16 is the deuterium labeled Decanedioic acid[1]. Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency[2].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Bertuzzi A, et al. Sebacic acid binding to human plasma albumin. Biochem Pharmacol. 1993 Feb 9;45(3):697-702.

Chemical & Physical Properties

[ Boiling Point ]:
294.5ºC(lit.)

[ Melting Point ]:
133-137ºC(lit.)

[ Molecular Formula ]:
C₁₀H₂D₁₆O₄

[ Molecular Weight ]:
218.34600

[ Exact Mass ]:
218.22100

[ PSA ]:
74.60000

[ LogP ]:
2.27640

Related Compounds

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