Diazepinomicin

Names

[ Name ]:
Diazepinomicin

[Synonym ]:
BU-4664L
ECO-4601
Diazepinomicin
TLN-4601
UNII-YPH994Y0RF

Biological Activity

[Description]:

Diazepinomicin (TLN-4601) is a secondary metabolite produced by Micromonospora sp. Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway and induces apoptosis. An anti-tumor agent for K-Ras mutant models[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway post Ras prenylation and prior to MEK activation[1].

[References]

[1]. Campbell PM, et al. TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling. J Mol Signal. 2010 Nov 2;5:18.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₄N₂O₄

[ Molecular Weight ]:
462.58100

[ Exact Mass ]:
462.25200

[ PSA ]:
98.48000

[ LogP ]:
6.58100

Related Compounds

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