Dihydralazine sulfate

Names

[ Name ]:
Dihydralazine sulfate

[Synonym ]:
EINECS 230-808-0
Depressan
1,4-dihydrazino-phthalazine,sulfate
MFCD00035271
dihydrazino-1,4-phthalazine sulfate
1,4-dihydrazinophthalazine sulfate(1:1)
Phthalazine,1,4-dihydrazino-,sulfate (1:1)
Phthalazine, 1,4-bis(hydrazinyl)-, sulfate (1:1)
1,4-Dihydrazino-phthalazin,Sulfat
1,4-dihydrazinylphthalazine sulfate (1:1)
1,4-Dihydrazinophthalazine hydrogen sulfate
(1Z,4Z)-1,4-dihydrazinylidene-1,2,3,4-tetrahydrophthalazine sulfate (1:1)
Dihydralazine sulphate
Sulfate de dihydralazine [French]
4-Hydrazino-1-hydrazono-1,2-dihydrophthalazine sulfate (1:1)
Dihydralazine sulfate
1,4-phthalazinedione, 2,3-dihydro-, dihydrazone, (1Z,4Z)-, sulfate (1:1)
dihydralazine

Biological Activity

[Description]:

Dihydralazine sulfate is an antihypertensive agent.

[Related Catalog]:

Signaling Pathways >> Others >> Others

[References]

[1]. Bijvank SW, et al. Ketanserin versus dihydralazine for the treatment of severe hypertension in early-onset preeclampsia: a double blind randomized controlled trial. Eur J Obstet Gynecol Reprod Biol. 2015 Jun;189:106-11.

Chemical & Physical Properties

[ Boiling Point ]:
648.3ºC

[ Molecular Formula ]:
C₈H₁₂N₆O₄S

[ Molecular Weight ]:
288.284

[ Flash Point ]:
345.9ºC

[ Exact Mass ]:
288.064087

[ PSA ]:
184.86000

[ LogP ]:
2.17560

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH8880000

CAS REGISTRY NUMBER :: 7327-87-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C8-H10-N6.H2-O4-S

MOLECULAR WEIGHT :: 288.32

WISWESSER LINE NOTATION :: T66 CNNJ BMZ EMZ &S-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 159 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 223 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: DNA damage

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 79500 ug/kg

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,605,1982

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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