Mal-C6-amine TFA

Names

[ Name ]:
Mal-C6-amine TFA

[Synonym ]:
1-(6-aminohexyl)pyrrole-2,5-dione,2,2,2-trifluoroacetic acid
1-(6-Aminohexyl)-1H-pyrrole-2,5-dione trifluoroacetate (1:1)
Acetic acid, 2,2,2-trifluoro-, compd. with 1-(6-aminohexyl)-1H-pyrrole-2,5-dione (1:1)

Biological Activity

[Description]:

Mal-C6-amine (TFA) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₇F₃N₂O₄

[ Molecular Weight ]:
310.270

[ Exact Mass ]:
310.114044

[ PSA ]:
100.70000

[ LogP ]:
1.70200

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2925190090

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

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