VU0155094

Names

[ Name ]:
VU0155094

[Synonym ]:
Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester
MFCD04625924
Methyl 4-(3-{[(4-acetamidophenyl)sulfanyl]acetyl}-2,5-dimethyl-1H-pyrrol-1-yl)benzoate

Biological Activity

[Description]:

VU0155094 is a potent, selective pan-Group III mGlu positive allosteric modulator with IC50 of 3.43/1.5/0.93 uM for mGlu8/7/4, respectively; displays >30-fold selectivity over groups I and II mGlus (mGlu1/2/3/5/6).

[References]

References 1. Jalan-Sakrikar N, et al. ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37. View Related Products by Target mGluR

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
667.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₄N₂O₄S

[ Molecular Weight ]:
436.523

[ Flash Point ]:
357.2±31.5 °C

[ Exact Mass ]:
436.145691

[ LogP ]:
4.87

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.606

Related Compounds

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