Benzoyloxypeoniflorin

Names

[ Name ]:
Benzoyloxypeoniflorin

[Synonym ]:
{(1R,2S,3R,5R,6R,8S)-3-[(6-O-Benzoyl-β-D-glucopyranosyl)oxy]-6-hydroxy-8-methyl-9,10-dioxatetracyclo[4.3.1.0.0]dec-2-yl}methyl 4-hydroxybenzoate
β-benzoyloxypaeoniflorin
Benzoic acid, 4-hydroxy-, [(1aR,2S,3aR,5R,5aR,5bS)-1a-[(6-O-benzoyl-β-D-glucopyranosyl)oxy]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-5b(3aH)-yl]methyl ester
Benzoyloxypeoniflorin
Benzoyloxypaeoniflorin

Biological Activity

[Description]:

Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC50 of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation[1][2][3].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[Target]

IC50: 0.453 mM (Mushroom tyrosinase)[1] NF-κB[2]

[References]

[1]. Ding HY, et al. Tyrosinase inhibitors isolated from the roots of Paeonia suffruticosa. J Cosmet Sci. 2009 May-Jun;60(3):347-52.

[2]. Lu Y, et al. The Screening Research of NF-κB Inhibitors from Moutan Cortex Based on Bioactivity-Integrated UPLC-Q/TOF-MS. Evid Based Complement Alternat Med. 2019 Mar 3;2019:6150357.

[3]. Koo YK, et al. Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. Pharmazie. 2010 Aug;65(8):624-8.

Chemical & Physical Properties

[ Density]:
1.6±0.0 g/cm3

[ Boiling Point ]:
789.1±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₀H₃₂O₁₃

[ Molecular Weight ]:
600.567

[ Flash Point ]:
258.6±0.0 °C

[ Exact Mass ]:
600.184265

[ PSA ]:
190.67000

[ LogP ]:
5.22

[ Vapour Pressure ]:
0.0±0.0 mmHg at 25°C

[ Index of Refraction ]:
1.699

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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