Zenidolol

Names

[ Name ]:
Zenidolol

[Synonym ]:
(+/-)-3-isopropylamino-1-(7-methylindan-4-yloxy)butan-2-ol
(2R,3R)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)butan-2-ol
erythro-DL-1-(7-Methylindan-4-yloxy)-3-isopropylaminobutan-2-ol

Biological Activity

[Description]:

Zenidolol (ICI-118551) is a selective β2 adrenergic receptor antagonist. Zenidolol inhibits β2-, β1- and β3-adrenergic receptor with Ki values of 0.7, 49.5 and 611 nM, respectively. Zenidolol can be used as an ocular hypotensive agent used for ophthalmic disease research[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Inflammation/Immunology

[References]

[1]. Hoffmann C, et al. Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):151-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₇NO₂

[ Molecular Weight ]:
277.40200

[ Exact Mass ]:
277.20400

[ PSA ]:
41.49000

[ LogP ]:
3.00080

Related Compounds

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