11-Hydroxytephrosin

Names

[ Name ]:
11-Hydroxytephrosin

[Synonym ]:
3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-6,7a-dihydroxy-9,10-dimethoxy-3,3-dimethyl-, (7aR-cis)-
(7aR,13aR)-6,7a-Dihydroxy-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one
3H-[1]Benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aH)-one, 13,13a-dihydro-6,7a-dihydroxy-9,10-dimethoxy-3,3-dimethyl-, (7aR,13aR)-

Biological Activity

[Description]:

11-Hydroxytephrosin is a potent inhibitor of NF-kappaB. NF-kappaB is known to play a crucial role in the regulation of genes controlling the immune system, apoptosis, tumor cell growth, and tissue differentiation[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[References]

[1]. Dat NT, et al. Phenolic constituents of Amorpha fruticosa that inhibit NF-kappaB activation and related gene expression. J Nat Prod. 2008;71(10):1696-1700.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
672.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₂O₈

[ Molecular Weight ]:
426.42

[ Flash Point ]:
236.8±25.0 °C

[ Exact Mass ]:
426.131470

[ PSA ]:
103.68000

[ LogP ]:
5.52

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.631

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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