Tetraethyl butane-1,4-diylbis(phosphonate)

Names

[ Name ]:
Tetraethyl butane-1,4-diylbis(phosphonate)

[Synonym ]:
Butandiyl-bis-phosphonsaeure-tetraaethylester
butanediyl-bis-phosphonic acid tetraethyl ester
TETRAETHYL BUTYLENEDIPHOSPHONATE
1,4-Bis-diaethoxyphosphoryl-butan
Tetraethylbutylene-1,4-diphosphonate
Butandiyldiphosphonsaeure-tetraaethylester
MFCD00015135

Biological Activity

[Description]:

Tetraethyl butane-1,4-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.099g/cm3

[ Boiling Point ]:
415.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₂₈O₆P₂

[ Molecular Weight ]:
330.29500

[ Flash Point ]:
218.7ºC

[ Exact Mass ]:
330.13600

[ PSA ]:
90.68000

[ LogP ]:
4.29880

[ Index of Refraction ]:
1.4465-1.4485

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
S24/25

Synthetic Route

Click to get detail synthetic route

Related Compounds

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