4-Hydroxyphenylboronic acid

Names

[ Name ]:
4-Hydroxyphenylboronic acid

[Synonym ]:
Boronic acid, B-(4-hydroxyphenyl)-
MFCD01074628
(4-Hydroxyphenyl)boronic acid
4-Hydroxyphenylboronic acid
4-[(Tetrahydro-2H-pyran-2-yl)oxy]-phenylboronic acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
351.4±44.0 °C at 760 mmHg

[ Melting Point ]:
>230 °C(lit.)

[ Molecular Formula ]:
C₆H₇BO₃

[ Molecular Weight ]:
137.929

[ Flash Point ]:
166.3±28.4 °C

[ Exact Mass ]:
138.048828

[ PSA ]:
60.69000

[ LogP ]:
0.85

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.582

[ Storage condition ]:
2~8℃

[ Water Solubility ]:
25 g/L

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2931900090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2931900090

[ Summary ]:
2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

Articles

Potent inhibitors of LpxC for the treatment of Gram-negative infections.

J. Med. Chem. 2nd ed., 55 , 914-923, (2012)

In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors...

Ishikawa, Shunpei; Manabe, Kei

Chem. Lett. 35 , 164-165, (2006)

Tetrahedron Lett. 48 , 845, (2007)