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Mcl1-IN-1

Names

[ CAS No. ]:
713492-66-1

[ Name ]:
Mcl1-IN-1

[Synonym ]:
{2-[(5-Chloro-8-hydroxy-7-quinolinyl)(2-pyridinylamino)methyl]phenoxy}acetic acid
Acetic acid, 2-[2-[(5-chloro-8-hydroxy-7-quinolinyl)(2-pyridinylamino)methyl]phenoxy]-

Biological Activity

[Description]:

Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC50=2.4 µM).

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer

[Target]

Mcl-1:2.4 μM (IC50)


[In Vitro]

Mcl1-IN-1 (Compound 1) is a Mcl-1 inhibitor, which demonstrates good Mcl-1 inhibition (IC50=2.4 µM) with no appreciable inhibition of Bcl-xL at 100 µM[1].

[References]

[1]. Richard DJ, et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9.


[Related Small Molecules]

Venetoclax (ABT-199) | ABT-263 | S63845 | ABT-737 | Obatoclax Mesylate | A-1210477 | A-1155463 | WEHI-539 hydrochloride | A-1331852 | Bax inhibitor peptide V5 | FX 1 | Gambogic Acid | TW-37 | UMI-77 | Acetate gossypol

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
681.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H18ClN3O4

[ Molecular Weight ]:
435.860

[ Flash Point ]:
366.0±31.5 °C

[ Exact Mass ]:
435.098572

[ LogP ]:
4.02

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.721

[ Storage condition ]:
2-8℃

Related Compounds