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2-Deoxy-2-fluoro-L-fucose

Names

[ CAS No. ]:
70763-62-1

[ Name ]:
2-Deoxy-2-fluoro-L-fucose

Biological Activity

[Description]:

2-Deoxy-2-fluoro-L-fucose, an L-fucose analog, is a fucosylation inhibitor. 2-Deoxy-2-fluoro-L-fucose inhibits de novo synthesis of GDP-fucose in mammalian cells. Fucosylation is a relatively well-defined biomarker for progression in many human cancers; for example, pancreatic and hepatocellular carcinoma[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

2-Deoxy-2-fluoro-L-fucose (2FF) (100-500 μM)) suppresses fucosylation in 4T1 cells[1]. 2-Deoxy-2-fluoro-L-fucose (100 μM; 4T1 cells) decreases phosphorylation of Smad 1/5 and Smad 2[1].

[References]

[1]. Herrera H, et al. Core-Fucosylated Tetra-Antennary N-Glycan Containing A Single N-Acetyllactosamine Branch Is Associated with Poor Survival Outcome in Breast Cancer. Int J Mol Sci. 2019;20(10):2528. Published 2019 May 23.

Chemical & Physical Properties

[ Density]:
1.335g/cm3

[ Boiling Point ]:
386.5ºC at 760 mmHg

[ Molecular Formula ]:
C6H11FO4

[ Molecular Weight ]:
166.14800

[ Flash Point ]:
187.6ºC

[ Exact Mass ]:
166.06400

[ PSA ]:
69.92000

[ Index of Refraction ]:
1.469

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds