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CHLORPHENAMINE MALEATES

Names

[ CAS No. ]:
7054-11-7

[ Name ]:
CHLORPHENAMINE MALEATES

[Synonym ]:
chlorphenamine maleate
chloropheniramine maleate
chlortrimeton

Chemical & Physical Properties

[ Melting Point ]:
130-135ºC(lit.)

[ Molecular Formula ]:
C20H23ClN2O4

[ Molecular Weight ]:
390.86100

[ Exact Mass ]:
390.13500

[ PSA ]:
90.73000

[ LogP ]:
3.14170

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
US6503000
CAS REGISTRY NUMBER :
7054-11-7
LAST UPDATED :
199806
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C16-H19-Cl-N2.C4-H4-O4
MOLECULAR WEIGHT :
390.90
WISWESSER LINE NOTATION :
T6NJ BYR DG&2N1&1 &QV1U1VQ -+-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
118 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
89 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
121 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
73 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
265 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
500 umol/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 24,181,1994

Safety Information

[ Hazard Codes ]:
T,Xi

[ Risk Phrases ]:
25-36/37/38

[ Safety Phrases ]:
36/37/39-45-36-26

[ RIDADR ]:
UN 2811 6.1/PG 3


Related Compounds