1-Chloro-3,5-dimethoxybenzene
Names
[ CAS No. ]:
7051-16-3
[ Name ]:
1-Chloro-3,5-dimethoxybenzene
[Synonym ]:
Benzene, 1-chloro-3,5-dimethoxy-
MFCD00008382
1-Chloro-3,5-dimethoxybenzene
EINECS 230-330-2
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
239.0±20.0 °C at 760 mmHg
[ Melting Point ]:
34-36 °C(lit.)
[ Molecular Formula ]:
C8H9ClO2
[ Molecular Weight ]:
172.609
[ Flash Point ]:
112.2±0.0 °C
[ Exact Mass ]:
172.029114
[ PSA ]:
18.46000
[ LogP ]:
2.99
[ Vapour Pressure ]:
0.1±0.5 mmHg at 25°C
[ Index of Refraction ]:
1.508
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CZ0320000
- CHEMICAL NAME :
- Benzene, 1-chloro-3,5-dimethoxy-
- CAS REGISTRY NUMBER :
- 7051-16-3
- BEILSTEIN REFERENCE NO. :
- 2327304
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C8-H9-Cl-O2
- MOLECULAR WEIGHT :
- 172.62
- WISWESSER LINE NOTATION :
- GR CO1 EO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01335
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
CZ0320000
[ HS Code ]:
2909309090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2909309090
[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
Articles
J. Org. Chem. 19th ed., 73 , 7481, (2008)
Suitable conditions were found for the Suzuki-Miyaura cross-coupling reaction of potassium cyclopropyl- and cyclobutyltrifluoroborates with aryl chlorides. Both of these secondary alkyl trifluoroborat...
The first total synthesis and structural determination of TMC-264. Tatsuta K, et al.Tetrahedron Lett. 49(25) , 4036-39, (2008)