maysin

Names

[ Name ]:
maysin

[Synonym ]:
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[4-hydroxy-6-methyl-5-oxo-3-(3,4,5-trihydroxy-6-methyl-oxan-2-yl)oxy-oxan-2-yl]chromen-4-one
Maysin
2,6-anhydro-1-deoxy-5-o-(6-deoxyhexopyranosyl)-6-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4h-chromen-6-yl]hex-3-ulose
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[4-hydroxy-6-methyl-5-oxo-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]chromen-4-one

Biological Activity

[Description]:

Maysin, a neuroprotective C-glycosyl-flavone, can be isolated from corn silk. Maysinshows protective activity against the damage caused by Syn amyloid aggregates-oligomers and fibrils. Maysinprevents oxidative stress and imbalance of intracellular calcium homeostasis, activating an autophagic degradative process. Maysincan be used for research of Parkinson's disease (PD)[1].

[Related Catalog]:

Research Areas >> Endocrinology

[In Vitro]

Maysin (2.5-15 μM；24 小时) 在 2.5 μM 和 5 μM 时对 SH-SY5Y 细胞显示出不显着的细胞毒性[1]。 Maysin (2.5-15 μM；4 小时) 在 SH-SY5Y 细胞中通过自噬激活防止 Syn 寡聚体的细胞毒性[1]。

[In Vivo]

Maysin (100 mg/kg 玉米须提取物，高 Maysin 含量；口服；每天一次，持续 4 周) 对大鼠没有毒性[2]。 Maysin (100 mg/kg 玉米须提取物；口服；每天一次，持续 4 周) 抑制 5α-R2 和 PCNA 的 mRNA 表达，降低 5α-R2、DHT 和 PSA 的浓度，改善良性前列腺增生 (BPH) 大鼠模型[2]。

[References]

[1]. Leri M, et al. Maysin plays a protective role against α-Synuclein oligomers cytotoxicity by triggering autophagy activation. Food Chem Toxicol. 2020 Oct;144:111626.

[2]. Kim SR, et al. Corn silk extract improves benign prostatic hyperplasia in experimental rat model. Nutr Res Pract. 2017 Oct;11(5):373-380.

Chemical & Physical Properties

[ Density]:
1.74g/cm3

[ Boiling Point ]:
938.8ºC at 760 mmHg

[ Molecular Formula ]:
C₂₇H₂₈O₁₄

[ Molecular Weight ]:
576.50300

[ Flash Point ]:
313.7ºC

[ Exact Mass ]:
576.14800

[ PSA ]:
236.81000

[ Index of Refraction ]:
1.745

Related Compounds

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