Bis-Tos-(2-hydroxyethyl disulfide)

Names

[ Name ]:
Bis-Tos-(2-hydroxyethyl disulfide)

Biological Activity

[Description]:

Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₂O₆S₄

[ Molecular Weight ]:
462.62400

[ Exact Mass ]:
462.03000

[ PSA ]:
154.10000

[ LogP ]:
5.95720

[ Storage condition ]:
2-8°C

Related Compounds

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