trimoprostil

Names

[ CAS No. ]:
69900-72-7

[ Name ]:
trimoprostil

Chemical & Physical Properties

[ Density]:
1.043g/cm3

[ Boiling Point ]:
528.2ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₈O₄

[ Molecular Weight ]:
378.54500

[ Flash Point ]:
287.3ºC

[ Exact Mass ]:
378.27700

[ PSA ]:
74.60000

[ LogP ]:
5.16240

[ Index of Refraction ]:
1.527

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UK8010000

CHEMICAL NAME :: Prosta-5,13-dien-1-oic acid, 15-hydroxy-9-oxo-11,16,16-trimethyl-, (5Z,11-alpha,13E,15R)-

CAS REGISTRY NUMBER :: 69900-72-7

LAST UPDATED :: 199009

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C23-H38-O4

MOLECULAR WEIGHT :: 378.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea

REFERENCE :: SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 62 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea

REFERENCE :: SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea

REFERENCE :: SHRIAI Shin'yaku to Rinsho. New Drugs and Clinics. (Shin'yaku to Rinsho Sha, 4-16-32 Fujimidai, Nerima-ku, Tokyo, 177, Japan) V.1- 1952- Volume(issue)/page/year: 35,2199,1986

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.