<Suppliers Price>

DMNQ

Names

[ CAS No. ]:
6956-96-3

[ Name ]:
DMNQ

[Synonym ]:
MFCD00184331
dmnq
Lopac-D-5439
2,3-dimethoxy-1,4-naphthalenedione
DiMeNQ
2,3-Dimethoxy-1,4-naphthoquinone
2,3-dimethoxy-1,4-naphtoquinone
2,3-Dimethoxynaphthoquinone
2,3-dimethoxy-1,4-NQ

Biological Activity

[Description]:

DMNQ is a redox cycling agent that generates both superoxide and hydrogen peroxide intracellularly in a concentration dependent manner. DMNQ increases ROS generation[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

[References]

[1]. Chacko BK, et al. The Bioenergetic Health Index is a sensitive measure of oxidative stress in human monocytes. Redox Biol. 2016 Aug;8:43-50.

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
392.5ºC at 760 mmHg

[ Molecular Formula ]:
C12H10O4

[ Molecular Weight ]:
218.20500

[ Flash Point ]:
177.6ºC

[ Exact Mass ]:
218.05800

[ PSA ]:
52.60000

[ LogP ]:
1.57000

[ Index of Refraction ]:
1.571

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2914690090

Customs

[ HS Code ]: 2914690090

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

Carvacrol and rosemary essential oil manifest cytotoxic, DNA-protective and pro-apoptotic effect having no effect on DNA repair.

Neoplasma 61(6) , 690-9, (2014)

For several thousand years natural products were successfully used to treat a variety of diseases and to maintain health in humans, but until now it is not fully known what causes these medicinal effe...

Posttranslational Regulation of Human DNA Polymerase ι.

J. Biol. Chem. 290 , 27332-44, (2015)

Human DNA polymerases (pols) η and ι are Y-family DNA polymerase paralogs that facilitate translesion synthesis past damaged DNA. Both polη and polι can be monoubiquitinated in vivo. Polη has been sho...

Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.

Genes Dev. 29 , 1018-31, (2015)

Copy number heterogeneity is a prominent feature within tumors. The molecular basis for this heterogeneity remains poorly characterized. Here, we demonstrate that hypoxia induces transient site-specif...


More Articles


Related Compounds