(E)-4,4,4-TRIFLUORO-1-PHENYL-BUT-2-EN-1-ONE
Names
[ CAS No. ]:
69304-49-0
[ Name ]:
(E)-4,4,4-TRIFLUORO-1-PHENYL-BUT-2-EN-1-ONE
[Synonym ]:
BV uracil
5-bromovinyluracil
Bromovinyluracil
MFCD00132885
Chemical & Physical Properties
[ Density]:
1.881g/cm3
[ Melting Point ]:
189-194ºC (dec.)(lit.)
[ Molecular Formula ]:
C6H5BrN2O2
[ Molecular Weight ]:
217.02000
[ Exact Mass ]:
215.95300
[ PSA ]:
65.72000
[ LogP ]:
0.42880
[ Index of Refraction ]:
1.685
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UV9020500
- CHEMICAL NAME :
- 2,4(1H,3H)-Pyrimidinedione, 5-(2-bromoethenyl)-, (E)-
- CAS REGISTRY NUMBER :
- 69304-49-0
- BEILSTEIN REFERENCE NO. :
- 0744244
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C6-H5-Br-N2-O2
- MOLECULAR WEIGHT :
- 217.04
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 200 mg/L
- REFERENCE :
- LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 38,281,1986
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
UV9020500
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Magn. Reson. Med. 42(5) , 936-43, (1999)
Using chemical shift-selective (19)F magnetic resonance (MR) imaging, we investigated the biomodulating action of 5-bromovinyluracil (BVU) on the degradation of the anticancer drug 5-fluorouracil (5-F...
Deoxyribosyl exchange reactions leading to the in vivo generation and regeneration of the antiviral agents (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5-ethyl-2'-deoxyuridine and 5-(2-chloroethyl)-2'-deoxyuridine.Biochem. Pharmacol. 35(10) , 1647-53, (1986)
In the rat, the highly potent anti-herpes drug (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdUrd) is rapidly converted to its base (E)-5-(2-bromovinyl)uracil (BVUra) through the action of pyrimidine nucleo...
Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine.J. Med. Chem. 29 , 213, (1986)
(E)-5-(2-Bromovinyl)uracil (BVU) and (E)-5-(2-bromovinyl)uridine (BVRU) were synthesized starting from 5-formyluracil via (E)-5-(2-carboxyvinyl)uracil or starting from 5-iodouridine via (E)-5-(2-carbo...