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Tigloylgomisin P

Names

[ CAS No. ]:
69176-51-8

[ Name ]:
Tigloylgomisin P

[Synonym ]:
gomisin B
Gomisin B
2-BUTENOIC ACID,2-METHYL-,(5R,6R,7S,13AS)-5,6,7,8-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YLESTER, (2E)-

Biological Activity

[Description]:

Tigloylgomisin P, a lignin, has anti-HIV activity with an EC50 of 37 μM. Tigloylgomisin P has anticancer effect[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[In Vitro]

Tigloylgomisin P displays weak cytotoxicity against A549 cells (GI50=18.77 μM), epidermoid carcinoma of the nasopharynx (KB; GI50=13.91 μM)[1].

[References]

[1]. Yan Lu, et al. Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens. Pharm Biol. 2013 Sep;51(9):1204-7.

[2]. Min Chen, et al. Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. J Nat Prod. 2006 Dec;69(12):1697-701.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H34O9

[ Molecular Weight ]:
514.56400

[ Exact Mass ]:
514.22000

[ PSA ]:
101.91000

[ LogP ]:
4.61040

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds