SPL 334

Names

[ Name ]:
SPL 334

[Synonym ]:
4-{[2-[(2-cyanobenzyl)thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl}benzoic acid
Benzoic acid, 4-[[2-[[(2-cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]-
4-({2-[(2-Cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl}methyl)benzoic acid
SPL-334
MFCD05032783

Biological Activity

[Description]:

SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> GSNOR

Research Areas >> Inflammation/Immunology

[In Vivo]

SPL-334 (0.1-1 mg/kg; 鼻内给药; 每日一次, 持续 7 天; 带有 DO11.10 CD4+ Th2 异种移植物的 BALB/c 受体小鼠) 导致过敏性气道炎症减少[1] . Animal Model: BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft[1] Dosage: 0.1 or 1 mg/kg Administration: Intranasal administration; daily, for 7 days Result: Caused a significant reduction in the influx of lymphocytes and eosinophils into the airways and the level of EPO in the BALF. Reduced the number of OVA-specific T cells and eosinophils during allergic airway inflammation. Reduced in peribronchial inflammation and mucus secretion during airway inflammation.

[References]

[1]. Ferrini ME, et, al. S-nitrosoglutathione reductase inhibition regulates allergen-induced lung inflammation and airway hyperreactivity. PLoS One. 2013 Jul 25;8(7):e70351.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
694.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₁₅N₃O₃S₂

[ Molecular Weight ]:
433.503

[ Flash Point ]:
373.5±34.3 °C

[ Exact Mass ]:
433.055481

[ LogP ]:
3.85

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.721

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.